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A myRAteam Member asked a question 💭
Amesbury, MA

How much is the max dosage for methotrexate? My rheumatologist just upped me to 10 2.5 pills a week.

June 27, 2016
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Answer Summary

Members shared their experiences with methotrexate dosing for rheumatoid arthritis, with most reporting that their rheumatologists cited 20mg... Read more

Members shared their experiences with methotrexate dosing for rheumatoid arthritis, with most reporting that their rheumatologists cited 20mg weekly (8 pills) as the standard maximum dose for RA, though some mentioned higher doses are used for other conditions like psoriasis or cancer. Several members described their doctors considering factors like height, weight, and individual tolerance when determining dosage, with many adding that if methotrexate alone doesn't provide relief at higher doses, a biologic medication is typically the next step. A recurring theme was the challenge of balancing effectiveness with side effects, including nausea, fatigue, and liver concerns, along with encouragement to advocate for yourself and try different options until finding what works best for your body.

A myRAteam Member

I take 10 2.5mg of MTX a week and I also take 1 1/2x dose for my weight of Orencia every 4 weeks. My Rheumatologist said that 25mg is the most a person can be on.

June 29, 2016
A myRAteam Member

That is the max dose according to my Rheumy.

June 28, 2016
A myRAteam Member

My RA doctor said 10 pills is the max dose. That is what I am on. NO relief at all. She added Enbrel about 4 months ago. That never worked either. She told me Humira was next. She says they normally give at least 3 months trial on each drug to see if it will work. You can always ask for something else if you don't see any results. We are are own best advocate. BEST WISHES.

June 29, 2016
A myRAteam Member

72 Nicole that should be your max 10 I was on 8 and found out I was not getting any relief I hope you can

June 29, 2016
A myRAteam Member

Hi I'm currently on 20mg of methotrexate x

June 28, 2016

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