Hair thinning with methotrexate is definitely something others have experienced — you're far from alone in this!
Many myRAteam members have shared similar experiences. One myRAteam member wrote that they lost 50 percent of their hair on methotrexate, and when it grew back, the texture was completely different and super Show Full Answer
Hair thinning with methotrexate is definitely something others have experienced — you're far from alone in this!
Many myRAteam members have shared similar experiences. One myRAteam member wrote that they lost 50 percent of their hair on methotrexate, and when it grew back, the texture was completely different and super curly. Others have described their hair becoming dry, wiry, or brittle. Here's why it happens: methotrexate works by blocking folate, a vitamin B that helps cells grow. It targets fast-growing cells involved in inflammation, but it can also affect fast-growing cells in hair follicles — which is what leads to thinning or texture changes.
The good news is that hair loss from methotrexate is usually mild and often improves if the medication is stopped or the dose is adjusted. Here are some steps that may help manage hair changes while on methotrexate:
- Talk to your rheumatologist — they may adjust your dosage or explore other medication options
- Take folic acid supplements — doctors often recommend these alongside methotrexate to help reduce side effects
- Be gentle when brushing or combing — avoid pulling too hard or styling too tightly
- Avoid tight hairstyles like tight buns, braids, or ponytails
- Be cautious with coloring or bleaching — check with your healthcare provider first, as it can further damage fragile hair
If you notice large clumps falling out suddenly or patchy hair loss, reach out to your healthcare provider right away.
August 29
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