Weight gain is not very common with leflunomide, but Simponi can sometimes make weight loss harder for some people. It really varies person to person, especially with rheumatoid arthritis and fibromyalgia.
Fatigue, pain, and reduced activity can also play a big role in weight changes. You are not alone in this struggle, many people with RA mention the same issue.
March 27
Does leflunomide make it hard to lose weight like Simponi?
Actually, leflunomide (Arava) tends to have the opposite effect. Weight loss is a common side effect of leflunomide, though the reasons aren't fully understood. So if you're struggling to lose weight, it's more likely related to Simponi rather than the leflunomide.
Show Full Answer
Does leflunomide make it hard to lose weight like Simponi?
Actually, leflunomide (Arava) tends to have the opposite effect. Weight loss is a common side effect of leflunomide, though the reasons aren't fully understood. So if you're struggling to lose weight, it's more likely related to Simponi rather than the leflunomide.
Simponi is a TNF-alpha inhibitor, and this type of biologic can cause modest weight gain. Research shows people typically gain between 2-5 pounds on TNF inhibitors, though everyone responds differently.
What might help:
- Talk to your doctor about your weight concerns. If the medication is controlling your RA well, the benefits may outweigh the weight gain
- Consider working with a physical therapist for movement strategies that work with your condition
- A registered dietitian can help create an eating plan that supports your overall health
- Some myRAteam members have found success with intermittent fasting and staying active while on TNF inhibitors
Remember, small weight gain on biologics can actually be a sign that your RA is under better control. But if you're concerned about how your medications are affecting you, your healthcare team can help evaluate whether adjustments might be beneficial.
March 26
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