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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
October 24, 2025
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Is anyone on leflunomide after switching from methotrexate?

Yes, leflunomide is a conventional DMARD that's commonly used for rheumatoid arthritis, similar to methotrexate. It's typically prescribed to be taken once or twice daily, so taking one tablet every day is a standard dosing schedule.

Many myRAteam members have Show Full Answer

Is anyone on leflunomide after switching from methotrexate?

Yes, leflunomide is a conventional DMARD that's commonly used for rheumatoid arthritis, similar to methotrexate. It's typically prescribed to be taken once or twice daily, so taking one tablet every day is a standard dosing schedule.

Many myRAteam members have experience with different DMARDs. Some have successfully transitioned between medications when their treatment plans needed adjusting.

Important considerations with leflunomide:

When taking NSAIDs (like ibuprofen) alongside leflunomide, there's a potential for the DMARD to cause a buildup of NSAIDs in your body, which could lead to additional side effects. Make sure your doctor knows about all medications you're taking, including over-the-counter pain relievers.

Like methotrexate, leflunomide requires regular monitoring. Your rheumatologist will likely order blood tests to check how your body is responding to the medication.

If you have questions about your specific transition or experience side effects, stay in close contact with your healthcare provider. They can help adjust your treatment plan to ensure the best results for managing your RA symptoms.

October 24, 2025
A myRAteam Member

Hi Denise Taylor

I can only say from my experience the best thing that ever happened to me was changing from Methotrexate to Leflunomide 1 tablet per day I am a new woman no more flares!!!
I am also on Yuflyma pen injections every 2 weeks which so complement Leflunomide.
Good luck hope it works for you as well.
________________________________

June 1

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