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Can someone tell me the difference between regular RA and Seronegative RA? I was diagnosed with Seronegative RA.

A myRAteam Member asked a question 💭
Albuquerque, NM
February 1, 2025
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myRAteam

The main difference between regular (seropositive) RA and seronegative RA lies in blood test results. Seropositive RA shows antibodies like rheumatoid factor (RF) or anti-cyclic citrullinated peptide (anti-CCP) in the blood, while seronegative RA does not. Both types share similar symptoms, such as joint pain and stiffness Show Full Answer

The main difference between regular (seropositive) RA and seronegative RA lies in blood test results. Seropositive RA shows antibodies like rheumatoid factor (RF) or anti-cyclic citrullinated peptide (anti-CCP) in the blood, while seronegative RA does not. Both types share similar symptoms, such as joint pain and stiffness, but seronegative RA can be harder to diagnose and may require imaging and symptom evaluation. Treatment approaches are generally the same.

February 1, 2025
A myRAteam Member

Sero negative makes me feel like I really don’t have it because all 4 of the Rheumatologists I have seen tell me the bloodwork doesn’t show anything. But my ANA was positive and some other speckled test was positive. I was posit for Sjögren but no one ever talks about that. They all said take the meds if it makes you feel better. It’s so discouraging.

February 11, 2025

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