Hi, I've been taking methotrexate for about 8 years and have not had a problem with it. I also take 5mg of Folic acid every day
Yes.. I had that problem but when I spoke to my doc about it, he upped my folic acid dose and that took care of the problem for me.
It's not uncommon for people taking methotrexate to experience mouth sores. Some members of myRAteam, a community for individuals with rheumatoid arthritis, have discussed developing mouth sores as a side effect of methotrexate. If you're having sores in the corners of your mouth, it could be related to the medication. It's Show Full Answer