Answer Summary

Members shared their experiences with methotrexate for rheumatoid arthritis, with many reporting success over periods ranging from several... Read more

Members shared their experiences with methotrexate for rheumatoid arthritis, with many reporting success over periods ranging from several months to 30 years, emphasizing the importance of taking folic acid daily to prevent mouth sores and noting that it can take four to six months to see results. Several members discussed helpful combinations, including methotrexate with prednisone, meloxicam, Celebrex, or biologics like Symponi, while others described side effects such as severe nausea, peripheral neuropathy from Arava, and in rare cases lung complications that required stopping the medication. A recurring theme was how differently individuals respond to the same treatment, with some tolerating methotrexate well for decades while others needed to switch medications, underscoring the value of the Vectra DA test in helping doctors tailor the best approach for each person.