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... Methotrexate may also be used in double therapy with another DMARD, such as: Azathioprine (Azasan, Imuran) Cyclosporine (Neoral, Sandimmune) Hydroxychloroquine (Plaquenil) Leflunomide (Arava) Sulfasalazine (Azulfidine) You may have heard of triple therapy — a treatment regimen for RA that combines medications like methotrexate, sulfasalazine, and hydroxychloroquine ...

... Sandimmune (Cyclosporine) is an immunosuppressive drug that dampens immune system activity by shutting down T-cell activity. Arava (Leflunomide) blocks DNA synthesis (creation of new DNA) in immune cells, stopping them from dividing and contributing to inflammation. ...

... Grapefruit can have a similar effect on calcineurin inhibitors, like cyclosporine (sold as Neoral and Sandimmune). ...