I've paused methotrexate while on antibiotics. The short term direction was not enough to trigger a flare, at least in my cases.

DO NOT take Bactrim with methotrexate!!! It’s a huge contraindication! Those two meds can’t be combined. Please call your doctor, rheumatologist or pharmacist for guidance.

Every time that I have started antibiotics I have to stop my RA meds. I take prednisone every day also because of my lung issues/asthma. I’m sure that if I did keep taking my RA meds that my immune system would be so compromised that I would not be able to fight an infection. So as soon as I finish my antibiotics which is a 14 day course I start my RA meds back. I get enough GI problems with the antibiotics. My GI tract would keep me in the bathroom if I continued the RA meds. Stay hydrated and get plenty of rest. Hugs to all.

I was told to stop RA meds for antibiotics and start them back after 7 days of my last pill left

I was told to stop taking methotrexate until I was done with the bactrim and the infection was cleared up. To message rheumatology when that happens and they'll let me know when to restart methotrexate.