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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myRAteam Member asked a question 💭
Cedar Lake, IN
October 20
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myRAteam

Great question! Benadryl (an antihistamine) is sometimes given before an Orencia infusion to help prevent or reduce the chance of an infusion reaction, which can feel similar to an allergic reaction.

These reactions are most common after the first infusion. Symptoms can include:

- Itching
- Hives or swelling
- Chills or fever Show Full Answer

Great question! Benadryl (an antihistamine) is sometimes given before an Orencia infusion to help prevent or reduce the chance of an infusion reaction, which can feel similar to an allergic reaction.

These reactions are most common after the first infusion. Symptoms can include:

- Itching
- Hives or swelling
- Chills or fever
- Difficulty breathing
- Changes in blood pressure

Most infusion reactions are mild, and pre-treating with an antihistamine like Benadryl helps keep things calm before they start. It's always worth checking with your rheumatologist or infusion nurse about exactly what pre-medications are used at your infusion center, as protocols can vary. If you ever experience any of these symptoms during or after an infusion, let your care team know right away.

October 20

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