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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myRAteam Member asked a question 💭
Pollocksville, NC

I have had RA for a number of years and have been controlled successfully with hydroxychloroquine and occasional prednisone. I now have giant cell arteritis and have been on high dose prednisone and actemra. With the tapering of the prednisone my RA symptoms have have really ramped up worse than ever.
Has anyone had experience in dealing with both?

October 17
 · 
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myRAteam

Managing RA alongside another inflammatory condition while tapering prednisone is genuinely challenging, and it makes sense that your RA symptoms are flaring — high-dose prednisone was likely keeping that inflammation suppressed too, and now that it's reducing, your RA is making itself known again.

It's worth having an open Show Full Answer

Managing RA alongside another inflammatory condition while tapering prednisone is genuinely challenging, and it makes sense that your RA symptoms are flaring — high-dose prednisone was likely keeping that inflammation suppressed too, and now that it's reducing, your RA is making itself known again.

It's worth having an open conversation with your rheumatologist about adjusting your RA treatment plan. A few things that may be worth discussing: - Actemra (tocilizumab), which you're already on, is actually also used to treat RA — so your rheumatologist may consider whether your current dose is optimized for managing both conditions
- Adding or adjusting a DMARD like methotrexate alongside hydroxychloroquine may help get RA back under control
- Biologics such as Humira or Orencia are options if conventional DMARDs aren't providing enough relief

The key takeaway is that your current treatment may need rebalancing now that prednisone is being tapered. Don't wait until your next scheduled appointment if symptoms are significantly worsening — reach out to your rheumatologist sooner.

Other myRAteam members have shared similar experiences of RA flaring during prednisone tapers, so you're definitely not alone in this.

October 17

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