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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
10 hours ago
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Poll: Members Share Which RA Symptoms Affect Them Most Day to Day Read Article...
A myRAteam Member

So the brain fog got better too? Sign me up for Cymbalta

6 hours ago
A myRAteam Member

Oh! Speaking of brain fog, mine was horrible! Cymbalta also helped with that once the side effects wore off! My memory is awful, so I still have some, just not as bad. I just wanted to add that since you reminded me 😂

8 hours ago (edited)
A myRAteam Member

Thank you so much for answering. I was leaning towards going on it, especially with seasonal depression soon on its way. Two RA drs. One says seronegative RA, one says possible RA stay on the methotrexate and add Cymbalta. I just want the head to stop giving the pain, I think I can handle a week of brain fog. Thank you and good luck with your health journey.

8 hours ago
A myRAteam Member

Hello Micky! I take cymbalta. It does help me with depression, but not pain and anxiety. My anxiety isn't terrible, so that's fine. It did absolutely zero for pain and fatigue. I have talked to other folks who had a great decrease in pain, however. You won't know if it will help you until you try it. I'm perfectly happy with it just controlling my depression, as that was getting pretty bad. I was scared to take it because of all the things that it can cause, but the side effects that I did have went away in a couple of weeks. I mostly felt like my head was in a fish bowl. Pretty spacy and felt like I wasn't looking through my own eyes if that makes sense. It was only really bad for about 5 days, then slowly went away completely. I hope this helps! Take care of yourself!

8 hours ago
myRAteam

Cymbalta (duloxetine) is actually an interesting option for people with RA, and your doctor is onto something worth considering! It works as a neuromodulator, meaning it helps reduce pain signals by adjusting the levels of chemical messengers like serotonin and norepinephrine between nerves.

For people living with RA, pain Show Full Answer

Cymbalta (duloxetine) is actually an interesting option for people with RA, and your doctor is onto something worth considering! It works as a neuromodulator, meaning it helps reduce pain signals by adjusting the levels of chemical messengers like serotonin and norepinephrine between nerves.

For people living with RA, pain management is multifaceted — it's not just physical, it's emotional too. Addressing both sides can make a real difference in quality of life. Here are a few things worth keeping in mind:

- Pain relief — The effect on pain is a well-recognized benefit, even if it started as a secondary observation
- Mood support — Managing anxiety and depression alongside RA can actually help reduce inflammation, since stress is known to trigger flares
- Side effects — Like all medications, Cymbalta comes with potential side effects that are worth discussing thoroughly with your doctor
- Combination approach — It works best as part of a broader plan that may include your existing RA treatments, lifestyle changes, and therapies like cognitive behavioral therapy (CBT)

It's always smart to have an open conversation with your rheumatologist about how it fits into your overall treatment plan, including any potential interactions with your current medications.

10 hours ago

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