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That's a really important thing to flag, and it's great that you're paying attention to it! Blisters on the bottom of the feet that aren't related to footwear could potentially be connected to methotrexate, as it is known to cause serious skin reactions in some people.

Skin-related side effects to watch for with Show Full Answer

That's a really important thing to flag, and it's great that you're paying attention to it! Blisters on the bottom of the feet that aren't related to footwear could potentially be connected to methotrexate, as it is known to cause serious skin reactions in some people.

Skin-related side effects to watch for with methotrexate include:

- Blistering
- Peeling
- Rashes
- Redness
- Fever alongside any skin changes It's really important to contact your rheumatologist as soon as possible about this. Skin reactions with methotrexate can be serious, and your doctor will want to know right away rather than waiting for your next scheduled appointment.

Don't stop taking your methotrexate without speaking to your doctor first, but do reach out promptly to describe what you're seeing.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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