Rituximab (Rituxan) is a biologic approved for RA when other treatments haven't worked. It targets B cells, which in RA produce harmful autoantibodies that attack healthy tissue.
Here's what to generally expect with Rituximab:
- Given as two IV infusions, two weeks apart
- Each infusion takes around 3–4 hours
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Rituximab (Rituxan) is a biologic approved for RA when other treatments haven't worked. It targets B cells, which in RA produce harmful autoantibodies that attack healthy tissue.
Here's what to generally expect with Rituximab:
- Given as two IV infusions, two weeks apart
- Each infusion takes around 3–4 hours
- A corticosteroid is given beforehand to reduce side effects
- Improvements may take 3+ months to notice
- Benefits can last 6–12 months or longer
- Your rheumatologist may suggest repeating every 6 months One myRAteam member shared that infusions can take a while to work, noting it took about two months to really kick in for them.
Another member who was initially resistant to infusions said after trying many other drugs, they gave it a go — and found it worked well with no side effects. As with any biologic, there are potential risks to be aware of:
- Increased risk of infections (respiratory, skin, urinary)
- Infusion reactions like itching, swelling, hives, or chills (most common after the first infusion)
- Possible reactivation of dormant viruses like hepatitis B — screening beforehand can help prevent this
Always discuss your full medical history with your rheumatologist before starting Rituximab so they can tailor the treatment safely for you.
August 13