I'm on Orencia monthly infusions for about 6 months now. It has really been helpful. I'm glad I changed my medicine.
July 23
Switching medications when one is working but causing uncomfortable side effects like itching is a really common experience for people managing RA. It's great that you're exploring options with your doctor!
Orencia (abatacept) works differently from Actemra — instead of targeting inflammatory proteins called cytokines, it Show Full Answer
Switching medications when one is working but causing uncomfortable side effects like itching is a really common experience for people managing RA. It's great that you're exploring options with your doctor!
Orencia (abatacept) works differently from Actemra — instead of targeting inflammatory proteins called cytokines, it blocks the activation of immune cells that cause joint inflammation. This different mechanism may mean a different side effect profile for you.
Here's what's helpful to know about Orencia:
- It can be given as an IV infusion or a self-injection under the skin
- IV infusions are typically given monthly after an initial loading period
- Most people begin noticing improvements within about 3 months
- Like all biologics, it can increase the risk of infections Regarding itching specifically, infusion reactions (which can include itching, hives, or swelling) are possible with any biologic infusion, though they're usually mild and manageable with antihistamines.
A myRAteam member shared that since their first drug infusion, they experienced unbearable itching, particularly on their hands and feet — so it's definitely worth flagging your history of itching with Actemra to your rheumatologist before starting Orencia.
Your doctor can monitor closely and have a plan ready if itching becomes an issue again. Don't hesitate to report any new itching symptoms right away!
July 19
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