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Perimenopausal and newly diagnosed serotonin negative RA, first dose of methotrexate 2 days ago.

A myRAteam Member asked a question 💭
Bristol, NH

Hello! Is there anyone else navigating RA ans perimenopause? I just took my first oral dose of methotrexate 2 days ago and the "hangover" is slowing me down more than I would like to admit. Anyone else have a similar experience?

June 28
 · 
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myRAteam

Welcome to the journey — and yes, that post-methotrexate "hangover" feeling is very real and very common. It even has a name: "methotrexate fog." It can include:

- Fatigue
- Headaches
- Mental fog and difficulty concentrating
- General feeling of being unwell

Many people feel this way the day or two after their dose Show Full Answer

Welcome to the journey — and yes, that post-methotrexate "hangover" feeling is very real and very common. It even has a name: "methotrexate fog." It can include:

- Fatigue
- Headaches
- Mental fog and difficulty concentrating
- General feeling of being unwell

Many people feel this way the day or two after their dose, especially in the beginning. The good news is that this often improves over time. A myRAteam member shared that in the beginning they felt worse the day after taking methotrexate, but after about six months, that problem went away entirely.

Methotrexate can take 3 to 6 weeks to start helping symptoms, and up to 12 weeks for the full effect — so patience is key right now, even when it's tough. It's really important to keep your rheumatologist informed about how you're feeling after each dose. They may be able to adjust timing, dosage, or suggest ways to ease the side effects.

Definitely don't stop taking it without consulting them first — stopping suddenly can increase the risk of RA flares.

June 28

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