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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myRAteam Member asked a question 💭
Clearwater Canada
June 21
 · 
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A myRAteam Member

I love my LDN. It has been a checks and balance if you will, with Celebrex.

June 25
myRAteam

That's a great question to be asking before making any changes to a treatment plan. Low Dose Naltrexone (LDN) is being studied as a potential option for managing RA symptoms, but it's considered an "off-label" use, meaning it hasn't been officially approved for RA treatment.

There isn't strong, widely available evidence Show Full Answer

That's a great question to be asking before making any changes to a treatment plan. Low Dose Naltrexone (LDN) is being studied as a potential option for managing RA symptoms, but it's considered an "off-label" use, meaning it hasn't been officially approved for RA treatment.

There isn't strong, widely available evidence specifically addressing the combination of LDN and methotrexate, so this is really a conversation to have with a rheumatologist before trying it. When taking methotrexate, it's important to be cautious about combining it with other medications because interactions can increase side effects or toxicity. Key things to keep in mind:

- Always inform all doctors and specialists about every medication being taken, including supplements
- Even over-the-counter medications can interact with methotrexate
- A pharmacist can also be a helpful resource for checking potential drug interactions

The safest step is to speak directly with a rheumatologist before adding LDN or any new medication to a methotrexate regimen. They can review the full picture and help make the safest decision.

June 21

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