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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
June 14
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A myRAteam Member

I had an extremely high ANA at first with not too much other high levels. I had a really bad rash called Granuloma Annulare that I had for years and didn't know it was an autoimmune condition. So at first my diagnosis was mixed connective tissue disease. As my health continued to get worse my levels changed. I was then diagnosed with Seronegative RA and mixed connective tissue. Sjogrens and fibromyalgia. I am like you I question if it's RA or something else. I trust my doctor. There are some on here that have later found out they have PsA and not RA. I know it's frustrating.
Good luck to you on this journey! ❤️🙏

June 14
A myRAteam Member

Thank you for your response.

June 14
myRAteam

That's a really understandable concern, and it's great that you're asking questions about your diagnosis. A high RF level like 249 is significant, but it's important to know that RF alone cannot confirm or rule out RA.

Around 80% of people with RA will have a positive RF test, but having a high RF doesn't automatically Show Full Answer

That's a really understandable concern, and it's great that you're asking questions about your diagnosis. A high RF level like 249 is significant, but it's important to know that RF alone cannot confirm or rule out RA.

Around 80% of people with RA will have a positive RF test, but having a high RF doesn't automatically mean you have RA. Other factors play a role too. Blood tests are just one piece of the puzzle. A full RA diagnosis typically involves:

- Physical examination — checking joints for swelling, tenderness, and range of motion
- Additional blood tests — such as anti-CCP antibodies and inflammation markers like CRP and ESR
- Imaging — ultrasound or MRI can detect subtle joint changes that blood tests might miss
- Symptoms — morning stiffness, fatigue, and joint pain are all considered

A myRAteam member put it well: "Blood tests for RA are only part of the diagnosis puzzle... they are never enough alone to diagnose RA." It's also worth noting that at 71, RF levels can sometimes be elevated without RA being present. This is worth discussing openly with your rheumatologist, who can look at the full clinical picture before drawing any conclusions.

Don't hesitate to ask your doctor for a more thorough workup if you feel uncertain — advocating for yourself is always the right move!

June 14

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Wolverhampton, UK