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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Has anyone been seronegative for RA and gotten a positive result on the avise test?

A myRAteam Member asked a question 💭

I am hoping on Monday to.get my labs drawn and sent out. I am curious to know what others have experienced from this test. Also my HLA-B27 was negative. Orthopedics reviewed my x-ray and stated she did not find any osteoarthritis as the findings stated. She did say it was possible for me to have small tears in the cartilage that doesn't show up on x-rays. She did state that the MRI did show a split tear of the peroneal brevis tendon on both ankles. She did tell me to keep up with crossfit as it… read more

June 6
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myRAteam

What a journey you've been on — navigating seronegative RA is genuinely challenging, and it's completely understandable to be looking for more answers before Monday's labs.

Seronegative RA means that standard blood tests don't detect the usual antibodies (anti-CCP or rheumatoid factor), which makes diagnosis much harder Show Full Answer

What a journey you've been on — navigating seronegative RA is genuinely challenging, and it's completely understandable to be looking for more answers before Monday's labs.

Seronegative RA means that standard blood tests don't detect the usual antibodies (anti-CCP or rheumatoid factor), which makes diagnosis much harder. This affects around 20% of people with RA. Some myRAteam members have shared similar frustrations, with one noting: "They ran blood work several times. The problem is I'm seronegative, so unfortunately I ended up getting worse before they could make a proper diagnosis based on clinical presentation." When standard blood tests are inconclusive, doctors typically look at a broader picture to diagnose seronegative RA, including:

- Physical examination and symptom history
- Inflammation markers like CRP and ESR blood tests
- Imaging such as ultrasound (which can detect joint inflammation) and X-rays
- MRI for soft tissue findings

Regarding staying active with CrossFit, gentle and consistent exercise is generally encouraged for RA management. However, given the tendon tears identified in your MRI, it would be worth discussing with your rheumatologist what level of activity is safe for your specific situation before continuing high-intensity workouts. Early diagnosis really does matter with RA. Research suggests that starting treatment within the first three to six months of symptoms can significantly reduce joint damage and improve long-term outcomes.

Hopefully Monday's labs bring some clarity — fingers crossed for answers that help move things forward! 🤞

June 6

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