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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myRAteam Member asked a question 💭
Pontypridd, UK

I have R.A / Osteoarthritis / Fibromyalgia / Lipoedema. I am really struggling to lose weight, I am in the obese bracket but also on Methotrexate. I do think that if I stop the Methotrexate and lost the weight my overall health would improve.
Any advice would be appreciated

June 6
 · 
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myRAteam

That's a really understandable question, and it's clear you're thinking carefully about your overall health — which is great. However, stopping Methotrexate without consulting your rheumatologist first is not recommended, as it can lead to serious RA flare-ups.

Methotrexate is a disease-modifying drug that slows RA Show Full Answer

That's a really understandable question, and it's clear you're thinking carefully about your overall health — which is great. However, stopping Methotrexate without consulting your rheumatologist first is not recommended, as it can lead to serious RA flare-ups.

Methotrexate is a disease-modifying drug that slows RA progression and prevents further joint damage. Stopping it suddenly could cause your RA to become very active again, leading to increased pain, swelling, and stiffness. The good news is that there may be options worth exploring with your doctor. Some things to discuss include:

- Whether Mounjaro and Methotrexate can be taken together safely
- Whether your RA is well-controlled enough to consider tapering Methotrexate gradually
- Alternative RA treatments that might suit your situation better
- Ways to manage Methotrexate side effects that may be contributing to weight challenges

It's really important not to stop Methotrexate on your own. Your rheumatologist can help weigh the risks and benefits based on your full health picture. If a flare does occur after any medication changes, some non-medication strategies that may help manage symptoms include:

- Reducing stress levels
- Prioritising sleep
- Using heat or cold therapy (warm baths, ice packs, heated blankets)
- Very gentle exercise, if your doctor approves
- Over-the-counter anti-inflammatory medications if appropriate

Always work closely with your healthcare team before making any changes to your treatment plan — your RA management is too important to risk without proper guidance.

June 6

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