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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myRAteam Member asked a question 💭
Southampton, Bermuda
April 5
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myRAteam

Will the day-after hangover feeling from Humira and methotrexate eventually go away?

Many people do find that the "hangover" feeling improves over time. A myRAteam member shared that in the beginning, they felt worse the day after taking methotrexate, but after about six months, this problem went away.

The day-after Show Full Answer

Will the day-after hangover feeling from Humira and methotrexate eventually go away?

Many people do find that the "hangover" feeling improves over time. A myRAteam member shared that in the beginning, they felt worse the day after taking methotrexate, but after about six months, this problem went away.

The day-after effects, sometimes called "methotrexate fog," can include fatigue, headaches, mental fog, and difficulty concentrating. While this is a known side effect, many people notice it lessens as their body adjusts to the medication.

If you're still experiencing these symptoms, there are strategies that might help:

* Taking methotrexate on Friday or Saturday so you have the weekend to recover
* Taking it after a meal when your stomach is full
* Taking a folic acid supplement
* Using medications to treat side effects like nausea

Talk to your doctor if the hangover feeling persists or becomes too difficult to manage. They can help adjust your treatment plan or suggest ways to minimize these effects while keeping your RA under control.

April 5
A myRAteam Member

I am on my6th week on taking methotrexate, the next day is always the worse, I am nauseated all day and most weeks stand to the following day too. I talked to a friend that has some years under his belt, and he told me the first months are the worse, to hang in there, because it gets better. I have hope

April 11

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