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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Has anyone tried different GLP-1 treatments and had improvements with weight loss while managing their RA, fibromyalgia, etc?

A myRAteam Member asked a question 💭
Childress, TX
February 28
 · 
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A myRAteam Member

@A myRAteam Member yes, I do take a GLP-1 for controlling my Diabetes and yes, I have lost Weight on it. I've lost 36 pounds and I honestly feel pretty great! Oh, my CMC Thumb joint and wrists still bother me, I'm not pain-free, but there are days I take very little to 0 Tylenol. I do also take Celecoxib which controls inflammation and Enbrel to combat the RA.

February 28
A myRAteam Member

What is the difference between semaglutide and tirzepatide?

February 28
myRAteam

What are patient experiences with GLP-1 medications for weight loss while managing rheumatoid arthritis?

While specific patient stories about GLP-1 medications aren't widely shared yet, recent research shows promising results for people with RA who are overweight or have obesity.

People taking GLP-1 drugs like semaglutide Show Full Answer

What are patient experiences with GLP-1 medications for weight loss while managing rheumatoid arthritis?

While specific patient stories about GLP-1 medications aren't widely shared yet, recent research shows promising results for people with RA who are overweight or have obesity.

People taking GLP-1 drugs like semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro, Zepbound) experienced:

* Greater reductions in RA disease activity
* Less joint pain
* More weight loss
* Improved cholesterol and blood sugar levels
* Significant drops in inflammatory markers (CRP and ESR)

Interestingly, the improvements in pain and inflammation weren't strongly tied to how much weight was lost, suggesting these medications may help reduce inflammation through other pathways.

However, about one-third of people stopped taking the medication. The most common reasons were gastrointestinal side effects like nausea or stomach upset, and insurance or cost barriers.

Currently, GLP-1 drugs aren't approved specifically for RA treatment. They're prescribed for type 2 diabetes, weight loss, and cardiovascular risk reduction. If you're curious about whether these medications might help your RA, talk with your rheumatology or primary care team about your full health picture.

February 28

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