How do you choose the best biologic for rheumatoid arthritis?
Choosing the right biologic for RA typically happens when other disease-modifying antirheumatic drugs (DMARDs) like methotrexate haven't provided enough relief. Your rheumatologist will help guide this decision based on your specific situation.
There are four Show Full Answer
How do you choose the best biologic for rheumatoid arthritis?
Choosing the right biologic for RA typically happens when other disease-modifying antirheumatic drugs (DMARDs) like methotrexate haven't provided enough relief. Your rheumatologist will help guide this decision based on your specific situation.
There are four main classes of biologics for RA, each targeting different parts of the immune system:
* TNF-alpha inhibitors - Block a protein that causes inflammation (examples: Humira, Enbrel, Remicade, Cimzia)
* B-cell inhibitors - Stop B cells from making autoantibodies that attack joints
* Interleukin inhibitors - Block inflammatory signaling proteins like IL-1 and IL-6 (examples: Kineret, Actemra)
* Selective costimulation modulators - Prevent immune cells from activating (example: Orencia)
Before starting any biologic, you'll need screening tests for infections like tuberculosis and hepatitis, plus baseline blood work to monitor your health during treatment.
The "best" biologic varies by person. Your doctor will consider factors like your disease severity, other medications you're taking, how you prefer to receive treatment (injection vs. infusion), and your overall health. Many biologics are used alongside methotrexate for better results.
Most biologics begin working within a few weeks, though some people notice improvement sooner. It's important to be patient and maintain your treatment schedule.
January 7
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