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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
December 29, 2025
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A myRAteam Member

I have been on methotrexate for close to 5 years and also an infusion every 2 months of a biologic. Two of my inflammation markers are now in normal area. I still have sore joints and some swelling especially during recent weather changes and stiffness but my flareups haven't been as severe. I feel optimistic.

January 10
A myRAteam Member

I stopped taking Methotrexate because it lowers your platelets which can cause bleeding as it did in my situation, since I stopped my platelets when up to a normal range and no more bleeding.

December 29, 2025
myRAteam

Are there issues with taking methotrexate and supplements like berberine that might affect liver enzymes?

Yes, this is an important concern. Methotrexate itself can affect liver function, which is why regular blood tests are recommended to monitor for liver problems. When taking methotrexate, it's crucial to inform your Show Full Answer

Are there issues with taking methotrexate and supplements like berberine that might affect liver enzymes?

Yes, this is an important concern. Methotrexate itself can affect liver function, which is why regular blood tests are recommended to monitor for liver problems. When taking methotrexate, it's crucial to inform your doctors about every supplement you're taking, including herbal ones like berberine.

Methotrexate can have drug interactions with many medications and supplements that may increase side effects or toxicity. These interactions can sometimes affect your liver enzymes and overall safety.

What you should do:

- Make sure your rheumatologist knows about all supplements you're taking
- Don't stop methotrexate or change doses without consulting your doctor
- Continue with regular blood testing to monitor liver function
- Discuss with your doctor whether berberine is safe to continue alongside methotrexate

Your health care team can help identify if the berberine is causing the elevated liver enzymes and determine the safest approach for managing your RA while protecting your liver health.

December 29, 2025
A myRAteam Member

You don't have any problems without Methotrexate? Doesn't it prevent the crippling effect or that's what I was told. I think I'm going to talk to my Rheumatologist. I'd like to stop taking it as well. I think it does more damage than good.
Thank you

December 30, 2025

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