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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
December 21, 2025
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A myRAteam Member

I have heard people who love It and many are very sick with dideceffects

December 23, 2025
A myRAteam Member

Ann, I'm going to go out on a limb and say, for some, yes, maybe there will be long term health issues. It's not impossible. For me personally? I've been on methotrexate for about four years now and it works great for me. At this point in time, I am willing to take my chances on my long term health, considering that this drug has my inflammation at normal levels and that means less cancer, less heart issues.... the list is really worthwhile.

December 23, 2025
A myRAteam Member

please don’t ever stop your meds. Consult your dr. I am baffled that so many people are on Steroids and methatroxate. There are so many biological out there and they come in pills, shots and infusions I’m on Orencia induction through my power pirt every 30 days. What it is done card don’t like to change meds. Read you on the RA drugs

before I every take a medicine I ask my pharmacist to print the COMPLETE
the FULL FDA report and read it before you you use the meds Pharmacist know the meds. Go to them not the little paper you get every time the ENTIRE FDA REPIRT
OK THANK YIU

December 22, 2025
A myRAteam Member

I stopped taking methotrexate. The side effects were very bad. I first used the pills Finally I gave myself an injection and it didn’t as bad side effects to. I felt like a witch . It was changing my personality and then I was done

December 22, 2025
myRAteam

Does taking methotrexate (MTX) for long periods cause long-term health issues?

Methotrexate can cause some serious side effects with long-term use, though they're relatively rare. The main concerns include:

* Liver damage
* Kidney damage
* Lung damage
* Decreased white blood cells (increasing infection risk)
* Decreased Show Full Answer

Does taking methotrexate (MTX) for long periods cause long-term health issues?

Methotrexate can cause some serious side effects with long-term use, though they're relatively rare. The main concerns include:

* Liver damage
* Kidney damage
* Lung damage
* Decreased white blood cells (increasing infection risk)
* Decreased blood platelets (causing abnormal bleeding)

To stay safe while on methotrexate long-term, regular blood tests are recommended - typically once a month - to monitor for potential problems with liver function and other organs. Your doctor will watch for any abnormalities in your blood work.

Taking folic acid daily is usually prescribed alongside methotrexate to help reduce side effects and lower the risk of liver problems. Other precautions include avoiding alcohol (since it can further stress the liver) and limiting sun exposure. What alternatives to biologics are available?

The search results primarily discuss methotrexate management and don't provide detailed information about other non-biologic alternatives. However, they do mention:

* Hydroxychloroquine (Plaquenil) - one myRAteam member mentioned taking this alongside methotrexate
* Adjusting methotrexate dosing or frequency
* Combination therapy with other DMARDs (disease-modifying antirheumatic drugs)

It's worth having a conversation with your rheumatologist about your concerns with long-term methotrexate use. They can discuss whether other non-biologic DMARDs might work for you, or if adjusting your current treatment plan could address your worries while still managing your RA effectively.

December 21, 2025

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Mondovi, WI