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I tried methotrexate pills a couple years ago but was so sick I could not eat or do anything and that was the baseline dose. It took me a month after stopping before I could eat food and another month before I could eat meat
I have been on prednisone but need to get off and now this rheumatologist is having me try the injections. I have a zofran prescription and I found zantac to help in combo with it. I am wondering besides these and taking the folic acid daily what else I can do to help side… read more
Answer Summary
Members responded to concerns about methotrexate side effects by strongly recommending the injectable form over pills, with many sharing that... Read more
Stop methotrexate and move on to biologics. It is my view that once your RA gets to certain level pills are too minimal to show much improvement. What pills do for your immune system ruins your stomach function. If you take medication because your taking medication, something is wrong. Hope you feel better.
For me, MTX injections bypass most of the digestive issues. I cannot keep running to the bathroom, either. I keep taking the folic acid (not with my MTX) and eating foods with a good supply of folic and found it helpful. I hope your providers can help you get these issues under control! ((Hugs)).
Leucovorin taken 12 hours after your MTX injection can help mitigate some of the side effects. It is a prescription. Ask your rheumy for a prescription. Good luck!!
For me, MTX was best when I took it on a Friday night with my pain meds, zophran (anti-nausea), and Zantac (anti-acid) and then sleep as long as my back would let me stay in bed. Sometimes as much as 16 hours (with the help of pain control). I would loose a half a day but it made the medication work better and lowered the side effects greatly.
My experience is that the injections are incredibly more tolerable than the oral dosages.
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