Do JAK inhibitors cause weight changes?
The evidence on JAK inhibitors and weight change is mixed. Different JAK inhibitors may affect weight differently.
What research shows:
- Tofacitinib (Xeljanz) may actually support healthy weight by helping transform white fat cells into more metabolically active brown fat cells
- Show Full Answer
Do JAK inhibitors cause weight changes?
The evidence on JAK inhibitors and weight change is mixed. Different JAK inhibitors may affect weight differently.
What research shows:
- Tofacitinib (Xeljanz) may actually support healthy weight by helping transform white fat cells into more metabolically active brown fat cells
- Upadacitinib (Rinvoq) didn't cause weight gain in RA clinical trials, but did cause some weight gain in people using it for atopic dermatitis
- The makers of Rinvoq list "increased weight" as a possible side effect
What to watch for:
If you notice significant weight changes after starting a JAK inhibitor, talk with your doctor. They can help evaluate whether the benefits of the medication outweigh any side effects and discuss alternative options if needed.
A physical therapist or registered dietitian can also help you manage weight through healthy eating and appropriate physical activity while on these medications.
AI-generated responses are not a substitute for medical advice. These services are not intended to
diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.
Managing Weight Gain From RA Medications
November 25, 2025
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