Are others taking 20mg methotrexate injection weekly plus 20mg leflunomide daily, and is it working?
Many myRAteam members take methotrexate injections at various doses, with approximately 19,000 members reporting they've used this medication. While experiences vary widely, some members find injections work better than Show Full Answer
Are others taking 20mg methotrexate injection weekly plus 20mg leflunomide daily, and is it working?
Many myRAteam members take methotrexate injections at various doses, with approximately 19,000 members reporting they've used this medication. While experiences vary widely, some members find injections work better than pills with fewer side effects.
One myRAteam member shared: "I had metho injections for two years with no side effects." Another noted: "I actually had worse symptoms with the injections but noticed it would only be for 24 hours or less and then I was great the rest of the week."
The combination you're asking about uses two different disease-modifying antirheumatic drugs (DMARDs). Methotrexate is typically the first-line treatment recommended for moderate to severe RA, while leflunomide is another conventional DMARD that's usually taken once or twice daily.
Your rheumatologist will likely monitor your response through routine blood tests to assess liver function and ensure your organs remain healthy on this combination.
Keep in mind that everyone responds differently to RA medications. What works well for one person may not work the same for another.
November 20, 2025
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