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Diagnosed with hashimoto’s and RA a year ago. Taking 20mg methotrexate once a week, 3mg folic acid daily, hydroxychloroquine daily and enbrel injection once a week. Not currently taking anything for the hashimoto’s. I would like to drop the methotrexate all together but have not been able to tolerate symptoms without it. Will be talking to my rheum dr to see if we can swap it for something else but was hoping to see what has helped others with hair loss and thinning. The weight gain is for… read more

August 11, 2025
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Hair loss affects about 1-9% of people taking methotrexate for RA. While folic acid supplements can help reduce some methotrexate side effects, they don't always prevent hair loss completely. The good news is that hair loss from methotrexate is usually mild and temporary, improving after stopping or adjusting the Show Full Answer

Hair loss affects about 1-9% of people taking methotrexate for RA. While folic acid supplements can help reduce some methotrexate side effects, they don't always prevent hair loss completely. The good news is that hair loss from methotrexate is usually mild and temporary, improving after stopping or adjusting the medication.

Here are some steps that may help manage hair loss while on methotrexate:
• Talk to your rheumatologist about adjusting your dosage
• Be gentle when brushing and styling your hair
• Avoid tight hairstyles that can cause additional strain
• Consider seeing a dermatologist to rule out other causes Many myRAteam members have shared similar experiences with hair changes while taking methotrexate. Some have noticed not just thinning but also changes in hair texture. While it's understandable to want to stop methotrexate completely, it's important to work with your rheumatologist to find the right balance between managing your RA symptoms and minimizing side effects. They can help determine if switching medications might be appropriate for your situation.

August 11, 2025

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