I have been on HCQ since I got dx 3 years ago. Had some relief but bloodwork still high. Tried methotrexate but liver enzymes went up. Humira was the next step. During the time it took to get approved I got bit by a tick. I had Lyme back in 2011 so Dr gave me 30 days of Doxycycline. After a couple weeks my RA symptoms improved. Happen to have an appt with pcp who said I should do a 90 day course of it. By week 6 my muscles came back to life. I hadnt been able to get up off the floor or step up onto anything for 2 years. My grip strength came back as well. There was a Dr many years ago who treated auto immune with doxy. He has a book called the road back by Dr Brown. I still have RA but I am able to function and no longer have fatigue. Idk if my RA was trigger by underlying Lyme or what but I definitely improved and its been over a year. I still take HCQ twice daily and need the occasional prednisone but I was on prednisone for 18 months straight prior to doxy. When the Humira nurse called to interview me and I told her how well I was doing she told me to call my rheumatologist because she didnt think I was a good candidate for Humira. I forgot to mention that my RA came on 2 weeks after I had Covid. I had mild symptoms for a few years that would come and go so never thought it could be RA. Woke up 2 weeks after covid in extreme pain, couldn't use my hands or walk. It was crazy. I hope u find something that helps u. This disease is awful.