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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
September 21, 2025
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myRAteam

Weight changes can occur with RA medications, and some weight gain may actually be a positive sign that your RA is better controlled. When symptoms improve, people may gain some weight as inflammation decreases and their body returns to a more normal state.

If you're concerned about the weight gain, it's important to Show Full Answer

Weight changes can occur with RA medications, and some weight gain may actually be a positive sign that your RA is better controlled. When symptoms improve, people may gain some weight as inflammation decreases and their body returns to a more normal state.

If you're concerned about the weight gain, it's important to discuss this with your healthcare provider. They can evaluate whether the benefits of your current treatment outweigh the side effects and determine if adjustments to your treatment plan are needed. Here are some steps you can take to manage weight while on RA medication:

• Work with a physical therapist to develop an appropriate exercise plan
• Consult with a registered dietitian for personalized nutrition advice
• Track your weight, symptoms, and overall health
• Discuss with your doctor about possibly adjusting medication dosage if needed

Remember that if your medication is effectively controlling your RA symptoms, the benefits may outweigh the challenge of weight gain. However, your healthcare team can help you find the right balance between managing your RA and maintaining a healthy weight.

September 21, 2025
A myRAteam Member

My weight was stable until I started Xeljanz XR, then it began to creep up. About 6 months ago I tried RINVOQ but couldn’t tolerate it. Back on Zeljanz and very frustrated. Both drugs are JAK inhibitors and have shown to cause weight gain in studies.
I appreciate your response!

September 25, 2025
A myRAteam Member

Hi Jeanette,
I was part of the clinical trials for Xeljanz and XeljanzXR and was on it for 12 years with no change in weight. It stopped working, after a hospital stay, when I was not allowed any of my medications for 5 days. I was prescribed Rinvoq, after 6 Mos, I am still not sure is is working.
I have an appointment with my Rheumatologist tomorrow, so will see what she says.
The two weeks in rehabilitation added 50 lbs, which I did not need. My Primary prescribed Mounjaro, so when I get weighed tomorrow I will know if that is working.
Big information day tomorrow...lol
I hope this helps.

September 25, 2025

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