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When taking methotrexate, it's important to be careful about which pain medications you combine it with. NSAIDs like ibuprofen and naproxen can be used alongside methotrexate for pain and inflammation management, but this should always be discussed with your healthcare provider first. IMPORTANT: Always inform your Show Full Answer

When taking methotrexate, it's important to be careful about which pain medications you combine it with. NSAIDs like ibuprofen and naproxen can be used alongside methotrexate for pain and inflammation management, but this should always be discussed with your healthcare provider first. IMPORTANT: Always inform your pharmacist and healthcare team about any medications you plan to take with methotrexate, even over-the-counter ones you've used safely before. Some drug combinations can increase side effects or toxicity of methotrexate, so it's crucial to get professional medical advice before starting any new pain medication.

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