Methotrexate is a first-line treatment for RA that works by calming your immune system and reducing inflammation. It typically takes 3-6 weeks to begin seeing improvement in symptoms, with full effects becoming apparent after about 12 weeks. The medication is usually taken once per week, either as a tablet, oral solution Show Full Answer
Methotrexate is a first-line treatment for RA that works by calming your immune system and reducing inflammation. It typically takes 3-6 weeks to begin seeing improvement in symptoms, with full effects becoming apparent after about 12 weeks. The medication is usually taken once per week, either as a tablet, oral solution, or injection.
Common side effects may include:
• Stomach issues (pain, nausea, diarrhea)
• Mouth sores or bleeding gums
• Skin changes
• Fatigue and headaches To help manage side effects, try these strategies:
• Take medication after meals
• Schedule doses for Friday/Saturday to recover over weekend
• Take folic acid supplements as prescribed
• Work with your doctor on anti-nausea medications if needed
Remember to continue taking methotrexate even when feeling better, as stopping could cause symptoms to return. Your doctor will monitor your progress with regular blood tests to ensure the medication is working safely.
August 5, 2025