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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myRAteam Member asked a question 💭
Pennsylvania Furnace, PA

other drugs I have tried for RA < Plaquenil < Pill

Humira

Enbrel

xeljanz < pill

rinvoq < pill

avsola < infusion

orencia Injectable

cimzia

actemra injectable

August 5, 2025
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myRAteam

Methotrexate is a first-line treatment for RA that works by calming your immune system and reducing inflammation. It typically takes 3-6 weeks to begin seeing improvement in symptoms, with full effects becoming apparent after about 12 weeks. The medication is usually taken once per week, either as a tablet, oral solution Show Full Answer

Methotrexate is a first-line treatment for RA that works by calming your immune system and reducing inflammation. It typically takes 3-6 weeks to begin seeing improvement in symptoms, with full effects becoming apparent after about 12 weeks. The medication is usually taken once per week, either as a tablet, oral solution, or injection.

Common side effects may include:
• Stomach issues (pain, nausea, diarrhea)
• Mouth sores or bleeding gums
• Skin changes
• Fatigue and headaches To help manage side effects, try these strategies:
• Take medication after meals
• Schedule doses for Friday/Saturday to recover over weekend
• Take folic acid supplements as prescribed
• Work with your doctor on anti-nausea medications if needed

Remember to continue taking methotrexate even when feeling better, as stopping could cause symptoms to return. Your doctor will monitor your progress with regular blood tests to ensure the medication is working safely.

August 5, 2025

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