Yes, weight loss can occur with RA and certain medications. Some myRAteam members have specifically asked about experiencing weight loss after their RA diagnosis. The medication leflunomide (Arava), which is a disease-modifying antirheumatic drug (DMARD), commonly causes weight loss as a side effect, though the exact Show Full Answer
Yes, weight loss can occur with RA and certain medications. Some myRAteam members have specifically asked about experiencing weight loss after their RA diagnosis. The medication leflunomide (Arava), which is a disease-modifying antirheumatic drug (DMARD), commonly causes weight loss as a side effect, though the exact reasons aren't fully understood. Weight loss in RA can sometimes be related to a condition called rheumatoid sarcopenia, where chronic inflammation leads to metabolic hyperactivity and muscle loss. Some people might not notice weight changes because lost muscle is replaced by fat, while others may experience noticeable weight loss without trying to lose weight.
If you're experiencing unexpected weight loss, it's important to discuss this with your healthcare provider as they can help determine if it's medication-related or due to other RA-related factors.
July 27, 2025