Yes, while muscle cramps are not one of the most common side effects of methotrexate (MTX), some myRAteam members have reported experiencing painful muscle spasms and cramps, particularly in their legs and toes. These muscle spasms can sometimes lead to cramping. Here are some ways to help manage muscle cramps while taking Show Full Answer
Yes, while muscle cramps are not one of the most common side effects of methotrexate (MTX), some myRAteam members have reported experiencing painful muscle spasms and cramps, particularly in their legs and toes. These muscle spasms can sometimes lead to cramping. Here are some ways to help manage muscle cramps while taking MTX:
• Stay well hydrated by drinking plenty of fluids
• Stretch your muscles before and after physical activity
• Try heat therapy like hot packs or heating pads
• Talk to your doctor about taking over-the-counter pain relievers
• Ask your doctor about folic acid supplements, which can help minimize side effects
If you're experiencing severe cramping, discuss this with your rheumatologist. They can evaluate the cause and potentially adjust your treatment plan.
July 3, 2025
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