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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
June 26, 2025
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Yes, corticosteroids, including cortisone injections, can cause weight gain through multiple mechanisms:

• They raise blood sugar levels
• Make cells resistant to insulin
• Increase hunger and food cravings
• Can cause fluid retention

Some of the weight gain, particularly from fluid retention, should decrease once you Show Full Answer

Yes, corticosteroids, including cortisone injections, can cause weight gain through multiple mechanisms:

• They raise blood sugar levels
• Make cells resistant to insulin
• Increase hunger and food cravings
• Can cause fluid retention

Some of the weight gain, particularly from fluid retention, should decrease once you complete the treatment course. If your RA symptoms haven't improved but you're experiencing unwanted side effects, it's important to discuss this with your doctor. They can:

• Evaluate if the current treatment is working effectively
• Consider adjusting the dosage
• Explore alternative treatment options
• Refer you to a physical therapist or registered dietitian for additional support with weight management

Remember that the goal is to find a treatment that improves your symptoms while minimizing side effects.

June 26, 2025

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