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I am 42 and newly dx with Seronegative RA, I am also a nurse so I’m worried about miserable side effects and not being able to do my job. This is the first treatment my Rheumatologist is trying. Any tips would be greatly appreciated!

November 19, 2024
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myRAteam

Starting methotrexate injections for seronegative rheumatoid arthritis (RA) can be a significant step. Here are some key points and advice based on my knowledge base:

Key Points
- Administration: Methotrexate injections are typically given once a week, on the same day each week. They come in prefilled, single-dose Show Full Answer

Starting methotrexate injections for seronegative rheumatoid arthritis (RA) can be a significant step. Here are some key points and advice based on my knowledge base:

Key Points:
- Administration: Methotrexate injections are typically given once a week, on the same day each week. They come in prefilled, single-dose autoinjectors (Rasuvo and Otrexup) designed for home use, which makes self-administration easier.
- Side Effects: Common side effects include gastrointestinal issues (nausea, vomiting, diarrhea), mouth sores, and occasional hair loss. These side effects often subside once the medication is stopped.
- Serious Side Effects: Rare but serious side effects include liver, lung, and kidney damage. Regular blood tests to monitor liver function are essential.
- Folic Acid: Taking 1 milligram of folic acid daily can help reduce some side effects like mouth sores and gastrointestinal issues.
- Alcohol and NSAIDs: Avoid alcohol and nonsteroidal anti-inflammatory drugs (NSAIDs) while on methotrexate.

Tips:
- Monitor Side Effects: Keep a close eye on any side effects and report them to your rheumatologist. Adjustments can be made to your treatment plan if necessary.
- Stay Hydrated: Drink plenty of water to help manage side effects and support kidney function.
- Routine Blood Tests: Ensure you have regular blood tests to monitor your liver and kidney function.
- Support Network: Engage with support groups like myRAteam to connect with others who understand life with RA.

Managing Work:
- Plan Around Side Effects: If you experience side effects like fatigue or nausea, try to schedule your injections before days off or lighter workdays.
- Communicate: Inform your employer about your condition and treatment to explore any necessary accommodations.

Starting a new treatment can be daunting, but with careful management and support, you can navigate this effectively.

November 19, 2024
A myRAteam Member

Been on it for a year! No problems!

December 1, 2024
A myRAteam Member

Thank you, I don’t think my doctor is prescribing the pens, I think it is a vial of the medication with a folic acid id supplement. We went with the injections rather than oral because I already have chronic gi issues so lets hope they don’t get worse

November 19, 2024
A myRAteam Member

I have Rasuvo injector pens - I love them as much as one can love a weekly injection of highlighter yellow medicine. It's the easiest injection for me, between this and Orencia. The pills were miserable. I am on folic acid to counteract the gastrointestinal issues with MTX.

November 19, 2024
A myRAteam Member

Stephanie,
It is good that you will be taking the folic acid as well.
May I suggest a med journal, date, time, med, reactions good/bad, that you can share with your Rheumatologist. On average it takes approx 3 months to know if a med is working or not.
Good Luck, let us know how you do.

November 20, 2024

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