Answer Summary

Members shared their experiences with different rheumatoid arthritis medication combinations in response to a question comparing methotrexate... Read more

Members shared their experiences with different rheumatoid arthritis medication combinations in response to a question comparing methotrexate with leflunomide versus methotrexate with hydroxychloroquine. Several members described finding success with various combinations, including methotrexate with hydroxychloroquine, sulfasalazine with leflunomide and hydroxychloroquine, and methotrexate with Orencia or Xeljanz, though some noted persistent challenges like trigger fingers or nodules. A recurring theme was that methotrexate appears to be a foundational medication that works well in combination with other drugs, but each person responds differently to treatment combinations.