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The context provided doesn't include specific details about individuals who have been on methotrexate for over 20 years. However, it does mention that people have had a variety of experiences with methotrexate, with some individuals reporting good results after being on it for several years. For instance, one member shared Show Full Answer

The context provided doesn't include specific details about individuals who have been on methotrexate for over 20 years. However, it does mention that people have had a variety of experiences with methotrexate, with some individuals reporting good results after being on it for several years. For instance, one member shared they have been on methotrexate for four years with good results so far, noting they tire easily. Another member mentioned taking methotrexate for two years and finding it effective. While these experiences highlight the drug's long-term use, they don't specifically cover a duration of over 20 years. Methotrexate has been a key treatment for rheumatoid arthritis since its FDA approval for this use in 1988, indicating it has been in use for over three decades, which suggests there could be individuals with such long-term usage.

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