Answer Summary

Members shared a wide range of experiences with methotrexate for rheumatoid arthritis, from no side effects at all over many years to nausea,... Read more

Members shared a wide range of experiences with methotrexate for rheumatoid arthritis, from no side effects at all over many years to nausea, fatigue, hair loss, and in one rare case, a serious blood infection. Several members offered practical strategies that helped them manage nausea, including taking the medication in the evening to sleep through it, switching from pills to injections, reducing the dosage with their doctor's guidance, and using anti-nausea medications like Zofran. A recurring theme was the importance of regular bloodwork to monitor for potential issues, the value of patience as the body adjusts to the medication, and the reassurance that many people find significant relief from RA symptoms with manageable or no side effects.