Answer Summary

Members shared mixed experiences with Leflunomide, with some finding it effective for years while others had to stop due to side effects. The... Read more

Members shared mixed experiences with Leflunomide, with some finding it effective for years while others had to stop due to side effects. The most common concerns centered on hair changes (thinning, dryness, and coarse texture), digestive issues (nausea and diarrhea, especially when starting or at higher doses), and less frequently, elevated liver enzymes or peripheral neuropathy. A recurring theme was that finding the right medication combination takes time and patience, with many members successfully pairing Leflunomide with biologics like Orencia or adjusting dosages to manage side effects while maintaining relief.