Answer Summary

Members shared mixed experiences with methotrexate for rheumatoid arthritis, with many reporting years of successful use without side effects,... Read more

Members shared mixed experiences with methotrexate for rheumatoid arthritis, with many reporting years of successful use without side effects, while others struggled with nausea, weakness, or digestive issues that led them to switch treatments or delivery methods. Several members offered practical advice, including taking folic acid on different days than methotrexate, trying the injectable form if pills cause stomach problems, and giving the medication a few weeks to work through initial rough patches. A recurring theme was that everyone responds differently to medication, so working closely with doctors through regular blood monitoring and being patient during the adjustment period are essential, as is balancing the fear of side effects against the serious consequences of untreated disease.