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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Rf factor positive ccp negative

A myRAteam Member asked a question 💭
Port Charlotte, FL

My rf factor is positive but my ccp is negative. I just changed to a new doctor so he ran a slew of test. I was being treated for ra for a long time and am on a biological. Did my previous doctor lie to me and take advantage of me and maybe I don't have ra or can I still have it with a negative ccp?

January 19, 2023 (edited)
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myRAteam

If your rheumatoid factor (RF) test is positive but your cyclic citrullinated peptide (CCP) antibody test is negative, it may indicate that you do not have rheumatoid arthritis (RA). However, RA can be difficult to diagnose, especially in its early stages. Your healthcare provider may need to conduct additional tests, such Show Full Answer

If your rheumatoid factor (RF) test is positive but your cyclic citrullinated peptide (CCP) antibody test is negative, it may indicate that you do not have rheumatoid arthritis (RA). However, RA can be difficult to diagnose, especially in its early stages. Your healthcare provider may need to conduct additional tests, such as:

- Erythrocyte sedimentation rate (ESR)
- Synovial fluid analysis
- C-reactive protein
- Antinuclear antibody

These tests can help show signs of inflammation, which is a symptom of RA.

July 12, 2024
A myRAteam Member

My Ana is positive and my RF factor is negative so my rheumatologist said that I am classified as having seronegative rheumatoid arthritis.

January 19, 2023
A myRAteam Member

Good morning Michele,

I'm the opposite of you RF negative, CCP positive. Since your RF is positive I would say you do have RA. The article below states you may be in the early stages of RA. Is your ANA positive?

https://medlineplus.gov/lab-tests/ccp-antibody-....

January 19, 2023

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