Answer Summary

Members shared diverse experiences with continuing or stopping methotrexate after adding biologics or Xeljanz, with many discontinuing it due... Read more

Members shared diverse experiences with continuing or stopping methotrexate after adding biologics or Xeljanz, with many discontinuing it due to liver enzyme elevation, side effects like nausea and hair loss, or lung issues, while others continue taking both medications successfully with good control. Several members described alternative combinations that worked well for them, including Xeljanz with leflunomide, Orencia alone, Enbrel with leflunomide, or methotrexate with CBD oil, with doses ranging widely based on individual tolerance and other health conditions like CLL. A recurring theme was the highly individual nature of RA treatment, the importance of monitoring liver function and side effects, and the need to work closely with doctors to find the right balance between disease control and medication tolerance.