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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myRAteam Member asked a question 💭
Pickering, ON

I’m currently on methotrexate tablets, however the nausea that comes with it is really kicking my butt right now. I know that it is available in injections as well. I’m curious if it’s worth it switching or sticking with the tablets and just dealing with the nausea.

January 29, 2021
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Answer Summary

Members overwhelmingly encouraged switching from methotrexate tablets to injections to reduce nausea, with many sharing that the injections... Read more

Members overwhelmingly encouraged switching from methotrexate tablets to injections to reduce nausea, with many sharing that the injections made a meaningful difference in how they felt, especially when taken at bedtime. Several members offered additional strategies that helped them manage nausea, including taking folic acid daily, splitting tablet doses throughout the day, and using ingredients found in cough syrup with doctor approval. A recurring theme was the importance of working closely with a rheumatologist to find the right combination and delivery method, as managing side effects is just as crucial as treating the disease itself.

A myRAteam Member

I was also nauseous with the tablets. The injections are so much better. I take mine at bedtime so any sicky feeling is gone when I wake up x

January 29, 2021
A myRAteam Member

I have been on 25 mL/10 pills of methotrexate for over 30 years which works well for me. Used both oral as well as injectable. Overall injectables been better.
For what it’s worth!

January 29, 2021
A myRAteam Member

Hi Jessa8 and welcome to the site. I was very nauseous when I was taking methotrexate tablets. In my case, switching to injections was much better. I was a bit scared to give myself the injections at first but now I'm a real pro! Ruth

January 29, 2021
A myRAteam Member

I just did my first self injection today of methotrexate because the pills were making me so nauseated. Hopefully this will be better!

February 4, 2021
A myRAteam Member

I was diagnosed 8 years ago and did a cocktail of drugs for 3 years and with my Rheumatologist continually telling me I was the worst case he’d seen in years I tried to take my own life. I finally got permission to get Enbrel and with the combination of Methotrexate and Cannibas I slowly went into remission, 5 years now and I take very minimal methotrexate, if I had my way it would be none. I had to completely change my lifestyle, but I’m happy I did and I’m thriving and my pain is limited it’s only the fatigue that annoys me most.

February 4, 2021

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