I take 6 tablets one day week. Taking all 6 at once made me nauseous, so I take 3 in the AM and 3 in the PM.

I personally couldn't take methotrexate because it made me so nauseous that I actually started to get sick.

Methotrexate keeps me moving. I take it right before bed on Sunday night. I just ignore any slight nausea when I’m sleeping. I would take half at bed time and half in the morning except I take Levothyroxine in the am.

How I’d love not to want to eat!! Lol. However, Methotrexate doesn’t do that to me! 😟

I get nausea and fatigue on 20mg methotrexate injection...I use anti..metics to stop the nausea...also methotrexate causes me to lose my appetite until 3rd day.