Answer Summary

Members shared their varied experiences with methotrexate for rheumatoid arthritis, with hair loss and fatigue emerging as the most commonly... Read more

Members shared their varied experiences with methotrexate for rheumatoid arthritis, with hair loss and fatigue emerging as the most commonly reported side effects, though many found relief through folic acid or biotin supplements, switching from pills to injections (or vice versa), or adjusting dosages. Several members described additional challenges including mouth sores, brain fog, frequent infections, and elevated liver enzymes, while others reported stable liver function even after years of use, emphasizing the importance of regular bloodwork and open communication with their rheumatologist. A recurring theme was the highly individual nature of medication response, with some members tolerating methotrexate well for decades while others had to discontinue due to debilitating side effects, underscoring the need for personalized treatment plans and patience in finding what works.