I've been on Actemra since June 2017 ( almost six months) and it has helped me incredibly. I do a weekly injection in my thigh. I've gone from being in incredible pain all over my body daily to almost being able to function 100% normally. Took about four months for the meds to kick in and be as effective as they have been. My hands still swell a little bit a few times a week and I still feel it in my shoulders and occasionally knees in the morning and evenings, but it's so small I don't even care. I've lost more weight than I would like since June (about 10lbs) but I've also been sick a few times and have had weight loss issues (as in losing too much) since I had a baby in Dec 2016, so I can't say it's definitely related. I have been having a lot of trouble putting weight back on which has been frustrating and I suspect is related to the Actemra.