During flare ups, I get it from head to toe all at once. Drs are stumped. Normally, Humira would take care of it, but now it does nothing. Meloxicam, Methotrexate, Prednisone, Indocin all ineffective. Since Jan 25, I have been to the er 6 times by early March. Thankfully have not had to go since. Spent more time than not bedridden. Pain gets so bad I just want to die. Literally.